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KMID : 1134819980270020344
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 2 p.344 ~ p.349
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Effects of Scoparone on Liver Function
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Cho Min-Kyoung
Hong Soon-Myung
Kim Byung-Sam
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Abstract
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The purpose of this study was carried out to investigate the effect of scoparone(6,7-dimethoxycoumarin) on liver function. Sprague-Dawley rats were treated with scoparone at a dose of 20㎎/㎏ body weight for 5 days. Hepatic bile flow, liver weight, BSP(bromosulfophthalein) biliary excretion, alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activities, malondialdehyde production and lactate dehydrogellase(LDH) release were assayed. Among them, ALT and AST activities, malondialdehyde production and LDH release were assayed by using primary hepatocyte cultures at a concentration of 0.l㎎/ml. Scoparone treatment had no effect on liver weight and hepatic bile flow. Scoparone treatment not only increased BSP biliary excretion, but also recovered the decreased BSP biliary excretion by CCl₄. Also scoparone significantly decreased with the increases of ALT and AST activities, malondialdehyde production and LDH release induced by CCl₄. These results suggested that scoparone could protect the liver damage by chemicals via promoting the liver excretory function.
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KEYWORD
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scoparone, liver function, biliary excretion, primary hepatocyte culture
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